The bulk of the park is covered in open savanna dotted with acacia and euphorbia trees. There are also large areas of swamp around lake Gorge. The extensive Maramagambo forest lies n the southeast of the park, and the forested Kyambura Gorge forms part of the eastern boundary, dividing the park from the chambura game Reserve. At least ten crater lakes lie within the reserve, the most easily visited cluster lying immediately north of the main road to Mweya lodge.
Queen Elizabeth national parks main tourist circuit lies north of the Kazinga channel and west of the Mbarara Kasese road, and it is focused around Mweya lodge on Mweya peninsula, which overlooks the point where the Kazinga channel exits Lake Edward. The less regularly visited Ishasha sector lies in the far south of the park, and it is based around the small Ishasha camp on the Zairean border.